In Silico Study of Avocado (Persea Americana Mill.) Seed Compounds Against PBP2a Receptor onStaphylococcus aureus

Authors

  • Meike Tiya Kusuma Department of Biology, Faculty of Science and Technology, State Islamic University of Maulana Malik Ibrahim Malang, Indonesia
  • Retno Susilowati Department of Biology, Faculty of Science and Technology, State Islamic University of Maulana Malik Ibrahim Malang, Indonesia

DOI:

https://doi.org/10.11594/

Keywords:

in silico, avocado seed, PBP2a, Staphyloccus aureus

Abstract

The nosocomial infection causes 1,4 million mortality every day in the world. International Nosocomial Infection Control Consortium (INICC) data shows that 84,4% nosocomial infection is caused by S. aureus that can cause skin infection. Avocado (P. americana) seed has been reported as an antibacterial agent and used for dermatological applications. This research was aimed to know the potential of antibacterial activity of ethanolic extract of avocado seed in silico study. The in silico test used molecular docking method with PyRx software between PBP2a as receptor and phytochemical compounds in avocado seed as a ligand. The result showed that rutin compound had the best potential to bind PBP2a (binding affinity: -18,2 kcal/mol). Thus, phytochemical active compounds in avocado seed can be recommended as an antibacterial drug and can increase the number of fibroblast cells caused by S. aureus.

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Published

2018-10-02

How to Cite

[1]
Meike Tiya Kusuma and Retno Susilowati, “In Silico Study of Avocado (Persea Americana Mill.) Seed Compounds Against PBP2a Receptor onStaphylococcus aureus”, Bioinform. Biomed. Res. J. , vol. 1, no. 2, pp. 45–48, Oct. 2018, doi: 10.11594/.

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